Platelet abnormalities include both thrombocytopenia (e.g. thrombocytopenic purpura) and thrombocytosis (e.g. primary thrombocythemia), and are best treated with medication, splenectomy, and so on. 1. Thrombocytopenia: common diseases include thrombocytopenic purpura, thrombotic thrombocytopenic purpura and so on. (1) Thrombotic thrombocytopenic purpura: preferred glucocorticosteroids, such as prednisone, dexamethasone, methylprednisolone, etc.; immunosuppressive drugs, such as vincristine, cyclophosphamide, azathioprine, and cyclosporine, etc., can also be used. (2) Thrombotic thrombocytopenic purpura: plasma replacement is preferred, followed by plasma transfusion. Antiplatelet drugs such as aspirin and prostacyclin are also available. Immunosuppressive drugs, such as vincristine, cyclophosphamide, cyclosporine A, and so on. Splenectomy if necessary. 2. Thrombocytosis: such as primary thrombocythemia, commonly used drugs include hydroxyurea, cyclophosphamide, nitrogen mustard phenylbutyrate and so on. Diseases causing platelet abnormality also include disseminated intravascular coagulation, platelet dysfunction disease, etc. Commonly used drugs are heparin, platelet transfusion and other methods can also be used. If the platelet test result is abnormal, it is recommended to consult a doctor in time to clarify the cause of the disease and carry out targeted treatment or therapy with the help of a doctor. The above drugs should be used under the guidance of a doctor.