The causes of neonatal jaundice include overproduction of bilirubin, insufficient ability of plasma albumin to bind bilirubin, poor ability of hepatocytes to process bilirubin, and increased enterohepatic circulation. 1. Excessive bilirubin production: the daily production of bilirubin in newborns is significantly higher than that in adults, which may be caused by the increased destruction and decomposition of red blood cells. 2. Insufficient ability of plasma albumin to bind bilirubin: free bilirubin is transported to the liver for metabolism by binding with albumin. Insufficient albumin in newborns, or decreased binding ability of albumin due to other reasons such as acidosis, can lead to decreased bilirubin metabolism, which will lead to neonatal jaundice. 3. Poor ability of liver cells to process bilirubin: after the liver cells take up bilirubin, they will metabolize bilirubin through uridine diphosphate glucuronosyltransferase (UDPGT) and excrete bilirubin out of the body. After the birth of newborns, the ability of hepatocytes to take up bilirubin is weak, and the content and activity of UDPGT in them are low, so their ability to process bilirubin is poor. 4. Increase in enterohepatic circulation: neonates have poor peristalsis, and the intestinal flora has not yet been fully established, which can increase the reabsorption of bilirubin in the intestinal tract. In addition, fetal feces contains more bilirubin, if excretion is delayed due to various reasons, it can also increase the reabsorption. If neonatal jaundice does not subside for a long time, you should consult a doctor to identify the cause of the disease and carry out the appropriate treatment under the guidance of the doctor, and avoid making blind judgment on your own, so as to avoid delaying the condition.