Colic generally occurs more intensely and the attack is usually described by the patient as a pain similar to that produced by writhing. This pain has its own specific location as well as symptom characteristics and treatment modalities, and the need for treatment is generally more urgent. Colic generally occurs in the internal hollow tissues and organs of the body. Common ones are such as the blood vessels, the urinary and biliary systems, and the digestive system. All of these tissues have a common feature – internal hollow. This is the case, for example, with angina pectoris, renal colic, biliary colic, and intestinal colic. There is a reason why it occurs within tissues and organs. This pain is internally hollow and can produce colic due to various diseases that cause tumors, blood clots, stones, and pathological states where food passage is blocked, in addition to holding normal blood, urine, bile, or food. In order to restore the normal state of these hollow organs and tissues, the body tries to expel these substances through rapid contraction of smooth muscles, and long-term, violent smooth muscle contraction causes colic. Because of the fatiguing nature of the muscle activity, the pain disappears after its activity ceases, and then starts again with severe pain. Therefore, colic usually does not last too long, but has a certain pause time, which is called by doctors as a paroxysmal attack of pain. In many cases, after a pause in pain, there is a further increase in pain intensity, which doctors call “paroxysmal increase in colic”. Colic is caused by a strong contraction of the smooth muscles of the hollow organs. Doctors treat this pain symptomatically with antispasmodic drugs, the purpose of which is to relieve the pain by relieving the violent activity of the smooth muscle. Colic usually occurs with more intense pain. Therefore, the patient will feel unacceptable and will mostly choose to go to the hospital promptly after the occurrence of this colic.