Waking up with a dry and sore throat may be caused by reflux pharyngitis, colds, and deviated nasal septum. 1. Reflux pharyngitis: after various factors lead to lower esophageal sphincter dysfunction, gastric acid and other gastric contents lose their limitation, reflux to the mucous membrane of the throat during sleep at night, corrosion and stimulation of the local mucous membrane, so you will wake up with a dry and sore throat. 2. Colds: viral infections lead to acute edema, oozing, bleeding and other inflammatory lesions of the mucous membrane of the throat, and body temperature increases heat dissipation increases, so you will wake up with a dry and sore throat. 3. Nasal septum deviation: congenital developmental deformity of the nasal septum deviation, caused by unilateral or bilateral narrowing of the nasal cavity, the gas through the nasal cavity is blocked, resulting in open-mouth breathing, causing the mucous membrane of the throat dry, so wake up with a dry and sore throat. Waking up with a dry and sore throat may be related to a variety of factors, and it is recommended to consult a doctor for a definitive diagnosis if symptoms persist or recur.