If the symptoms of connective tissue disease patients are mild, it generally does not matter; however, if the clinical symptoms are severe, and accompanied by soft tissue atrophy, limb necrosis and other serious complications, it is more important, and the serious cases can even be life-threatening. Connective tissue disease is a group of etiology is not known, involving multi-organ multi-system connective tissue disease, mainly including lupus erythematosus, dermatomyositis, scleroderma, dry syndrome, rheumatoid arthritis, polyarteritis nodosa and rheumatic fever. Their development is related to factors such as genetics, viral infections, and abnormal immune function. Patients with connective tissue disease may have skin damage such as rashes and blisters, or symptoms such as low-grade fever, fatigue, joint pain, muscle weakness, cough, shortness of breath, dry mouth, blurred vision, etc. When lungs, kidneys and other organs are involved, interstitial pneumonitis and renal failure can occur, and in severe cases, life can be jeopardized. In general, if the connective tissue disease is in the early stage of the disease, the degree of illness is mild, after standardized treatment, can slow down the progress of the disease, the condition control is stable, it does not matter. If the connective tissue disease is in the late stage, and accompanied by soft tissue atrophy, limb necrosis, joint deformities, severe cases can appear renal failure, pulmonary hypertension, and lead to the right heart load increase and right heart failure, etc., will affect the patient’s quality of life, at this time, the situation is more important. It is recommended that patients with connective tissue disease seek timely medical treatment, and actively cooperate with doctors to standardize diagnosis and treatment.