There is no data to show which kind of cancer hurts the most, and most of the cancers will have pain symptoms when they reach the late stage. Clinically, the common malignant tumors with obvious pain in the late stage are pancreatic cancer, liver cancer and bone metastasis in the late stage of cancer. 1. Pancreatic cancer: from the patient’s point of view, the pain of pancreatic cancer is more serious in the late stage. Abdominal pain is the first symptom of pancreatic cancer, and once discovered, most of them are in the middle or late stage, which can produce severe pain, and some of them have pain radiating to the back, left shoulder, etc., and the pain is unbearable during the attack. 2. Hepatocellular carcinoma: patients with hepatocellular carcinoma mainly suffer from epigastric distension and pain, the tumor cells will pull the hepatic peritoneum, and when the tumor grows bigger and bigger, the pain will become more and more obvious, and it will be accompanied by abdominal distension and ascites. 3. Bone metastasis of advanced cancer: Bone metastasis will occur when the primary tumor reaches the advanced stage, and the tumor cells will keep destroying the bone strength and produce severe pain, which is mostly sharp and stabbing, and it is unbearable for patients when it is serious. If advanced cancer patients have pain symptoms, they should consult doctor in time and treat the symptoms under doctor’s guidance, so as to reduce patients’ pain and improve their quality of life as much as possible.