Generalized osteosarcoma is a malignant tumor originating from bone, although it is difficult to be cured completely, after active treatment, the five-year survival rate is 20%~80%, and some patients’ survival rate can be up to 60%~80%, which is related to the patient’s age and the severity of the disease. Osteosarcoma is a malignant tumor that originates from bone tissue, which is most common in adolescents, and the site is mostly in the long bones of the limbs. It is characterized by the ability of malignant tumor cells to directly generate bone-like tissues, and it is easy to recur and easy to metastasize. The main treatment for osteosarcoma is comprehensive treatment combining surgery and chemotherapy. Although it is difficult to completely cure the early limited low malignant osteosarcoma, the five-year survival rate after treatment can reach 60%~80﹪; in the late stage of highly malignant osteosarcoma with extensive distant metastasis, it is difficult to cure it even after limb amputation, and the five-year survival rate is only 20﹪~30﹪. When symptoms such as bone and joint pain occur, it is recommended to consult a doctor in time for a clear diagnosis and treatment under the doctor’s guidance.