Non-steroidal anti-inflammatory drugs are divided into non-selective cyclo-oxygenase inhibitors and selective cyclo-oxygenase inhibitors two categories of non-steroidal anti-inflammatory drugs have their own strengths and weaknesses, and the specific indications for the drug are also different, according to the patient’s condition needs to be selected, there is no such thing as “the safest non-steroidal anti-inflammatory drugs”. Non-selective cyclooxygenase inhibitors include ibuprofen tablets, indomethacin, aspirin, acetaminophen, etc., while selective cyclooxygenase inhibitors include meloxicam, nimesulide, celecoxib, etc., and the two types of non-steroidal anti-inflammatory drugs have their own advantages and disadvantages. Non-selective cyclooxygenase inhibitors are more likely to cause gastrointestinal discomfort, electrolyte disorders, and other adverse drug reactions than selective cyclooxygenase inhibitors, but selective cyclooxygenase inhibitors, although gastrointestinal irritation is relatively small and slow-acting, but there is a certain degree of cardiovascular and cerebrovascular risk. Non-steroidal anti-inflammatory drugs should be selected and used under the guidance of a physician, and it is recommended that patients go to the relevant departments of regular hospitals for detailed counseling, do not self-medication.