With the change in lifestyle and diet, the number of people suffering from diabetes is increasing day by day. Diabetes is a group of metabolic diseases mainly characterized by high blood sugar. According to clinical statistics, diabetic patients are more than three times more likely to develop coronary heart disease than non-diabetic patients. Moreover, once diabetic patients develop coronary heart disease, their coronary artery lesions tend to be diffuse and much more severe than those of non-diabetic patients, with a high incidence of left heart dysfunction and cardiac events and a worse prognosis. So what are the reasons? In diabetic patients, regardless of abnormal glucose metabolism, it is often accompanied by disorders of protein and lipid metabolism. abnormal lipoprotein metabolism in type 2 diabetic patients is mainly manifested by high triglycerides, high LDL-C and low HDL-C. Lower blood HDL-C and elevated triglycerides with concomitant high LDL-Cemia are decisive risk factors for coronary heart disease. Therefore, it is necessary to lower glucose along with strict lipid lowering in order to reduce the occurrence of coronary heart disease. Hyperglycemia can cause damage to tissues through a number of reactions (e.g. glycosylation oxidation, protein kinase C activation, etc.) processes. Increased blood glucose can damage the arterial wall, which in turn promotes LDL oxidation, which causes damage to the coronary vascular intima, the initial condition for plaque formation. The poorer the blood glucose control, the more severe the coronary intima damage. Glucose uptake by cardiac myocytes also occurs in diabetic patients, resulting in inadequate myocardial function and reduced myocardial contractility, which affects cardiac function. Also in diabetic patients, glucose concentration in the blood is higher and glycosylated hemoglobin is increased, making the red blood cells less able to carry oxygen and the myocardium susceptible to hypoxia. In diabetic patients, platelet adhesion and aggregation are increased, blood viscosity is increased, red blood cell deformation ability is reduced, and thrombosis is prone to occur. These are the reasons that increase the occurrence of coronary heart disease and are also the reasons that patients who already have coronary heart disease are more likely to have an acute myocardial infarction. The proportion of diabetic patients with concomitant hypertension is four times higher than that of non-diabetic patients, and the incidence of cardiovascular autonomic neuropathy is also significantly higher. These cause patients to exhibit a range of abnormalities such as impaired heart rate regulation and altered coronary hemodynamics. Hypertension is also an independent risk factor for coronary heart disease and can significantly increase the risk of coronary heart disease. Therefore, patients with diabetes should not be shy about taking care of their disease. Once you have diabetes, it does not mean that your life is gray from now on. Some diabetics refuse to take glucose-lowering drugs and refuse to use insulin, all of which can increase their risk of cardiovascular disease. In fact, after certain treatment and prevention, it is completely possible to get your blood sugar under control. Only when blood sugar is well controlled, the risk factors associated with coronary heart disease are reduced, and then the chances of developing coronary heart disease are naturally reduced.