High transaminases may be caused by diseases such as hepatitis B viral hepatitis, alcoholic liver disease, autoimmune hepatitis, drug-induced liver injury, or after strenuous exercise, excessive fatigue, alcohol consumption and high-fat food. Depending on the cause of the disease, the treatment is different. If it is physiological elevation, it can be reduced to normal by paying attention to rest, stopping drinking alcohol and taking a light diet. 1. Hepatitis B viral hepatitis: anti-viral drugs, such as entecane and veramivudine, can be given to promote the decline of aminotransferases. 2. Alcoholic liver disease: first of all, we should quit drinking, and we can give polyene phosphatidylcholine, reduced glutathione and other medicines to promote the repair of liver cells, and promote the decline of aminotransferases. 3. Autoimmune hepatitis: Prednisone, azathioprine and other drugs can be given. 4. Pharmacological liver injury: reduced glutathione, glycyrrhizic acid preparations, N-acetyl cysteine and other drugs can be given. There are many reasons for high aminotransferase, it is recommended to consult a doctor, improve the examination, clarify the cause of the disease, and use medication under the guidance of the physician, do not take medication without authorization.