The long-term local periocular use of glucocorticoids by patients can cause primary open-angle glaucoma, fundus lesions, and other diseases, etc., as follows: 1. Open-angle glaucoma: Causes primary open-angle glaucoma. Individuals in the outpatient clinic are very sensitive to local application of glucocorticoids, and the degree of IOP elevation may be very large within a few days, possibly to 30-40 mmHg or more, so it is important to routinely check the IOP and atrial angle before application. 2. 2. Fundus lesions: It is necessary to see if there are any potential lesions in the fundus optic disc, and to do a good job of recording and tracking, because this kind of hormonal glaucoma can occur at any time during the long-term application of glucocorticoids, so once you decide to use glucocorticoids for a long time, you must regularly monitor the IOP and see the changes in the fundus optic disc. 3. Other diseases If long-term systemic application is used, it can cause cataracts and induce or aggravate herpes simplex virus keratitis. If the corneal epithelium is incomplete, local long-term application may also cause fungal growth.