Generalized lymph node enlargement without fever needs to undergo lymph node biopsy and improve relevant examinations to clarify the diagnosis. Common causes include non-specific lymphadenitis, acute and chronic leukemia, AIDS and so on. Patients with advanced malignant tumors often have painless lymph node enlargement, which plays a certain role in suggesting the metastasis of the tumor. For simple viral infection or inflammation caused by lymph node enlargement, symptomatic treatment, such as antiviral therapy, etc. is needed. For generalized lymph node enlargement, syphilis, AIDS, etc., we need to consult the doctor in time, complete the relevant examination, clarify the original disease, and actively cooperate with the doctor to carry out the treatment. Lymph nodes, as an important immune component of the human body, have a certain role in indicating disease, patients need to pay enough attention to actively identify the primary cause of the disease, and standardize the treatment under the guidance of the doctor, so as to avoid delaying the condition.