Levofloxacin and norfloxacin are comparable in the treatment of diarrhea caused by sensitive bacteria, because both drugs belong to the fluoroquinolone class, and both can be used as drugs of choice for intestinal infections, respiratory tract infections, and urinary tract infections. Norfloxacin is a second-generation fluoroquinolone drug, while levofloxacin is a third-generation fluoroquinolone drug, as the same family of drugs, levofloxacin is equivalent to the status of the big brother, with broad-spectrum antibacterial properties, on common Gram-positive bacteria, Gram-negative pathogenic bacteria have a strong antibacterial effect, for chlamydial infections, mycoplasma infections also have a very good treatment effect. Norfloxacin is equivalent to the younger sister of the family, is the weakest member of the family, for most of the Enterobacteriaceae bacteria have good killing effect, but is still the weakest effect of similar drugs, for gram-positive cocci and Pseudomonas aeruginosa, it is almost inactive. Norfloxacin is currently recommended only for simple lower urinary tract infections and intestinal infections, so the two drugs are equivalent for diarrhea caused by sensitive bacteria, while levofloxacin has a broader therapeutic range.