Prednisone acetate is a glucocorticoid drug, long-term use of patients suddenly stopping the drug may cause rebound phenomenon, discontinuation syndrome and other situations. 1. rebound phenomenon: in the long-term use of prednisone acetate to treat the condition of the drug will produce dependence on this drug, in the condition is not yet fully controlled, suddenly stopping the drug, can lead to the recurrence or aggravation of the original disease. 2. Discontinuation syndrome: long-term use of prednisone acetate tablets suddenly stopped, such as infection, trauma, surgery and other emergencies, there may be a part of the adrenal crisis, mainly manifested as fatigue, nausea, vomiting, low blood pressure or even shock and other occurrences, and some may also appear myalgia, arthralgia, fatigue, weakness, loss of appetite, fever and other symptoms. When applying prednisone acetate for treatment, it should be applied under the guidance of a doctor, and according to the condition as well as the doctor’s instructions to slowly reduce the dosage until stopping the drug, do not stop or increase or decrease the dosage without authorization.