Leg pain after walking too much may be caused by exertion, osteoarthritis, varicose veins of the lower limbs, etc. It can be treated by general treatment, medication (such as ibuprofen), surgery and so on. 1. Exertion: Less exercise and more walking may lead to accumulation of lactic acid in the muscles, resulting in leg pain, which can be relieved by resting, and the lower limbs can be elevated during rest, which is favorable for venous return. 2. Osteoarthritis: This disease will lead to joint pain, which will be aggravated after activities. Patients should rest appropriately and reduce activities; they can use drugs such as ibuprofen and tamoxifen to relieve pain, and they can also inject hyaluronic acid into the joints to lubricate the joints, which is conducive to the relief of pain; joint deformity and abnormal joint function can be treated by joint cleaning and joint fusion. There may be many reasons for walking more leg pain, exclude physiological reasons for timely consultation and treatment, and strictly comply with the doctor’s prescription medication.