In the past 20 years, laparoscopic technology has developed rapidly due to its minimally invasive features and has been widely used in the diagnosis and treatment of general surgery, urology and gynecological diseases, becoming the gold standard for the treatment of some benign diseases. However, can laparoscopic technology be used to treat malignant tumors of the gastrointestinal tract? Can the treatment be complete? Many patients and families still have such questions. In recent years, the results of some clinical randomized controlled trials in Europe, the United States, Japan and Korea have been published in international authoritative journals, providing evidence-based medical evidence for laparoscopic treatment of GI tract tumors. (1) Application of laparoscopic techniques in the treatment of gastric cancer Gastric cancer ranks fourth among the most common malignant tumors in the world. China, Japan and Korea are the countries with high incidence of gastric cancer. Currently, laparoscopic treatment of gastric cancer has been more widely performed in Japan and Korea. In a 2008 Korean study, which is the largest international RCT of gastric cancer, 82 of 164 cases of early gastric cancer underwent laparoscopic surgery and 82 underwent open surgery, and the results showed that laparoscopic surgery was associated with less bleeding, shorter incision length, early postoperative bedtime, faster recovery of gastrointestinal function, less pain medication, and higher quality of life compared with open surgery. An Italian RCT study treated 70 cases of gastric cancer including progressive gastric cancer. The results suggest that laparoscopic surgery can meet the principle of radical treatment of gastric cancer, and the 5-year disease-free survival rate and 5-year overall survival rate are consistent with open surgery, and laparoscopic surgery has the advantage of minimally invasive, and the incidence of surgical complications is lower than that of open surgery. Our department has completed 300 cases of laparoscopic-assisted radical gastric cancer surgery, and there were no serious postoperative complications related to laparoscopy, which is completely consistent with open surgery in terms of tumor radicality. The results of the study have been published in the journal “World Journal of Gastroenterology”. In addition, our department has successfully treated many complicated and difficult gastric cancer cases with laparoscopic techniques, which were interviewed and reported by CCTV and Beijing TV. (2) Application of laparoscopic technology in the treatment of gastric mesenchymal tumors Gastrointestinal Stromal Tumors (GIST) are rare tumors occurring in the digestive tract and belong to a kind of mesenchymal tumors, GIST can occur in any part of the digestive tract, among which gastric mesenchymal tumors account for 60%-70%, GIST is not sensitive to traditional radiotherapy and chemotherapy. Surgical resection is still the treatment of choice for GIST. The biology of GIST itself determines that laparoscopic resection can meet the principles of its radical treatment, and several foreign studies have shown that laparoscopic resection meets the treatment principles of GIST, and its efficiency and recurrence rates are similar to or better than those of open surgery. The advantages of laparoscopic surgery include less bleeding, less trauma, fewer complications and faster recovery. In North America, gastric mesenchymal tumors have become one of the most common indications for laparoscopic gastrectomy. Laparoscopic treatment of gastric mesenchymal tumors is performed in a variety of ways, including: wedge resection of the stomach, intraluminal resection of the stomach, and partial resection of the stomach (Bi I or II GI reconstruction). Some foreign scholars have classified gastric mesenchymal tumors into three types according to the location of the tumor: type I – tumor located in the fundus/great curvature of the stomach; type II – tumor located near the pylorus/sinus; type III – tumor located near the gastric lesser curvature/esophagogastric junction. For type I gastric mesenchymal tumor, laparoscopic gastric wedge resection is feasible; for type II, laparoscopic assisted distal gastrectomy is feasible; for type III, laparoscopic transgastric luminal tumor resection is feasible. Our department has accumulated rich experience in laparoscopic treatment of gastric GIST and has achieved good efficacy. (3) The application of laparoscopic technology in the treatment of colorectal cancer In the past 10 years, the results of several large RCT studies in Europe and the U.S. have been published one after another; the MRC CLASICC trial is a 27-center RCT study in the U.K. Among 794 cases of colorectal cancer, 526 cases underwent laparoscopic surgery and 268 cases underwent traditional open surgery. The COLOR trial is the largest international RCT of laparoscopic treatment of colon cancer, with 29 centers in Europe participating. 627 of 1248 colon cancer cases underwent laparoscopic surgery and 621 underwent open surgery. The results showed no significant difference between the laparoscopic group and the open group in terms of 5-year disease-free survival and 5-year overall survival. This evidence-based medical evidence suggests that laparoscopic techniques can treat colorectal cancer, meet the principles of radical tumor treatment, achieve outcomes that are fully consistent with those of open surgery, and that laparoscopic surgery is minimally invasive to the body in a way that traditional open surgery cannot match. The National Comprehensive Cancer Network guidelines, which are currently recognized as the authoritative guidelines in the field of oncology, recommend laparoscopy for the radical resection of colon cancer. The American Association of Colorectal Surgeons also recommends laparoscopic radical resection of colon cancer. In conclusion, the current evidence-based medical evidence proves that laparoscopic techniques can treat gastrointestinal tract tumors and their radicality is consistent with open surgery. It is believed that with the publication of more RCT studies, laparoscopy will become the gold standard for the surgical treatment of gastrointestinal malignancies.