The H. pylori eradication quadruple combination of drugs has a bismuth agent, two antibiotics, and a PPI. Commonly used bismuth agents are colloidal bismuth pectin and bismuth potassium citrate. Commonly used antibiotics are clarithromycin, metronidazole, tetracycline, and levofloxacin. Commonly used PPIs are rabeprazole, omeprazole, pantoprazole, and so on. Specific medication choices must follow medical advice. Usually 10 to 14 consecutive days are needed for eradication. Adverse reactions such as nausea, vomiting and dizziness may occur when taking quadruple drugs. If obvious discomfort occurs, you should consult your doctor in time and adjust the drugs under the doctor’s guidance. Regular review is required after eradication of the drugs to avoid recurrence. Eradication of Helicobacter pylori should be under the guidance of the doctor to choose the appropriate drugs for treatment, do not blindly use drugs to avoid adverse reactions.