Neonatal jaundice is a physiological phenomenon in the early neonatal period and is one of the clinical manifestations of many pathological diseases after birth. If it exceeds the normal value or appears too early and subsides too late, it is pathological, and if not actively treated, it can easily cause serious sequelae such as nuclear jaundice. Drug therapy is one of the main treatments for neonatal jaundice. So what medications should be taken for neonatal jaundice? Commonly used drugs for the treatment of neonatal jaundice are as follows. (1) Glucose and alkaline solution: glucose can supply heat to jaundiced babies and nourish the heart, liver, brain and other important organs, and alkaline solution can reduce metabolic acidosis. (2) Plasma or albumin: supplying albumin linked to bilirubin can reduce free unconjugated bilirubin and prevent bilirubin encephalopathy. (3) Enzyme inducer: It can induce the activity of glucuronosyltransferase in the endoplasmic reticulum of hepatocyte sliding surface and reduce serum unconjugated bilirubin, commonly used phenobarbital. (4) Adrenocorticotropic hormone: it can prevent the reaction between antigen and antibody, reduce hemolysis, and such drugs also promote the ability of hepatocyte glucuronosyltransferase to bilirubin binding. In addition, herbal preparations can also be used to treat neonatal jaundice. For example, the anti-yellowness and profit punch, Artemisia insipidus soup, three yellow soup, etc.. Commonly used herbs such as Yin Chen, Gardenia, Rhubarb, Scutellaria, Che Qian Zi, Bamboo Roo, Chen Pi, etc. For physiological jaundice does not require special treatment, pathological jaundice needs to find the cause, in addition to the above treatment methods to reduce jaundice, it is important that some need to be symptomatic.