Feeling burning and itching with Tacrolimus Ointment should be addressed promptly with your doctor, depending on the specific situation. For patients who use Tacrolimus Ointment for the first few days, a burning sensation, tingling and itching may occur on the local skin after use, and this burning sensation and itching usually lasts for a few minutes to a few hours, averaging about 15 to 20 minutes, which is an adverse reaction resulting from the use of the medication, and usually disappears as the skin adapts to it. However, tacrolimus ointment is only suitable for short-term use or intermittent long-term use. If you have been using it for some time and experience such symptoms, stop using the medication, talk to your doctor as soon as possible, and adjust your medication. People who are allergic to tacrolimus ointment or its ingredients should not use it, pregnant and lactating women as well as children under two years of age should not use it, and others, such as the elderly with underlying diseases and adolescents who are growing and developing, need to use it with caution. Precautions: tacrolimus ointment should not be used in immune-compromised adults, avoid use in potentially worsening dermatoses and malignant skin diseases such as mycosis fungoides, etc., remove infected foci from the treatment site before use, and avoid sunlight exposure during treatment. Adverse reactions to tacrolimus ointment are more frequent, such as anemia, anorexia, anxiety, dry eyes, dizziness, and seizures. The medication should be used in strict compliance with the doctor’s instructions, and should not be used blindly on its own.