Blood will naturally clot when in contact with abnormal surfaces, which is a normal physiological phenomenon in the human body. However, in some cases, such as in patients with heart valve disease who have undergone prosthetic valve replacement, in order to prevent blood from clotting after contact with the prosthetic valve and forming a thrombus, coagulation needs to be inhibited, and this requires the use of anticoagulant drugs. Warfarin is the most widely used anticoagulant in clinical practice and is effective in inhibiting the formation of small emboli on the prosthetic valve, making it an essential lifelong drug for patients after valve replacement. Adjusting the dose of warfarin to maintain coagulation within the appropriate range is the most important postoperative issue for patients. A blood test for prothrombin time will tell how long the blood takes to clot, which in turn will determine the dosage of warfarin. The therapeutic range for a patient on Favalin is that his or her clotting time reaches 1.5 to 2 times normal. The normal clotting time is 12 seconds, thus, most patients need to maintain a prothrombin time (PT) between 18-24 (16-20) seconds, a prothrombin activity (PTR or PTA) between 30%-50%, or an international normalized ratio (INR) between 2.0-3.0; of these, the INR is the most stable and reliable and the most important indicator to guide the patient’s medication. During hospitalization, the clotting time is checked daily. After discharge from the hospital, you may have it checked every 1-2 weeks. The frequency of clotting time checks can be tapered over 1-2 months once your dose of Favarox has stabilized. You will need to have your clotting time checked every 4-6 weeks for as long as you are taking Favarox. It is important to remember the following rules when taking Favarox: 1) Do not take any medications containing aspirin while taking Favarox; 2) Learn to read the label on the medicine bottle. (5) increased menstruation; (6) hemoptysis or vomiting of blood; (7) severe abdominal pain; (8) severe headache; (9) excessive petechiae. Learn to adjust the dose of favalin in milligram units rather than by the number of pills; 5) Limit alcohol intake to no more than 2 drinks in 24 hours, alcohol interferes with the absorption of favalin; 6) Need to increase the frequency of monitoring the bleeding and clotting times when taking other medications or having a change in diet structure. There are several manufacturers of Favarine available. You should choose one and not change it easily. If you need to change it, you should monitor your clotting blood and adjust it to the appropriate dose. Keep a record of the results of your clotting time and the dose adjustment of Favarox. The table below can be used as a guide when you are discharged from the hospital. Patients with valve replacements require additional infection precautions. The valve prosthesis is an artificial object in the body. Any bacteria that enter the bloodstream can begin to grow around the prosthetic valve. Bacteria that grow at the valve can lead to valve malfunction and infection of the endocardium. To prevent infection, antimicrobials are given whenever there is a possibility of bacteria entering the bloodstream. Antimicrobials are given before and after performing: 1. All dental procedures, including scaling, fillings and extractions. Encourage regular dental cleanings to maintain good oral hygiene. Tell your dentist before your visit that you are taking Favarine and that short-term discontinuation of it may be necessary. 2. any minor or major surgery 3. any invasive medical operation or examination, as blood vessels may be pierced and bacteria can enter. You may need antimicrobials if you have a fever or have some kind of infection. This includes skin, respiratory, vaginal, and urinary tract infections. Not all colds are caused by viruses, and antibiotics may be needed to treat colds.