Cancer patients usually have to face pain, and sometimes the fear of pain and the fear of end-of-life suffering even exceeds the fear of death. Then, it is an important responsibility of pain physicians to help patients overcome their fear and get out of the misunderstanding of analgesic drugs and analgesic treatment methods. First of all, most patients apply conservative methods: on the one hand, oral and dermal opioids plus some auxiliary drugs can control pain and improve pain threshold; on the other hand, actively treating the source of pain, such as patients with bone metastatic pain, applying analgesic drugs and actively carrying out bone protection therapy is also an important part of cancer pain treatment, which is very meaningful for improving the quality of life and decreasing the dosage of opioid drugs. Secondly, a few patients with poor effect of conservative methods, i.e., poor effect of applying analgesic drugs, or some patients with serious adverse reactions such as severe dizziness, constipation, urinary effort, etc. can not tolerate oral, patch, intramuscular or intravenous application of opioids, then some minimally invasive treatments should be considered. However, patients with advanced cancer are often accompanied by pain in multiple places, and interventional treatments such as neurodestructive treatment one by one face the question of whether they can tolerate the surgery, However, patients with advanced cancer often have multiple pains, and interventional treatments such as nerve destruction one by one face the problems of whether they can tolerate the surgery, radiation exposure, etc., and cannot solve the pain problem fundamentally and are very expensive.