Gastrointestinal spasm is a tonic contraction of the smooth muscles of the stomach and intestines, causing pain in the abdomen. Drugs that can be used to relieve gastrointestinal spasm, also known as gastrointestinal motility inhibitors, are mainly anticholinergic drugs, including choline derivatives and synthetic substitutes. These drugs can affect the muscles of the whole body while relieving gastrointestinal spasm, so care must be taken when using them, especially for patients with high blood pressure and heart disease. In recent years, there are many drugs specifically for gastrointestinal spasm, which are widely used in the clinic, mainly trimebutine, pivirimium bromide, oxybutynin, alverine, esavirenz, etc. They are characterized by good antispasmodic effect and few side effects.