Bone cement is a calcium phosphate. Calcium phosphate bone cement (CPC) is also called self-curing calcium phosphate. It consists mainly of calcium phosphate powder and liquid phase (distilled water, solution, blood). When the two are mixed into a slurry, hydration and solidification occurs within a short period of time and under a certain physiological environment (37 degrees, 100% humidity), and the final product is the main component of bone —- hydroxyapatite. I. Characteristics: CPC has excellent bioactivity, biocompatibility, self-curing ability and easy plasticity. Zhang Feng, Oncology Center, Shandong Thoracic Hospital II.History: In 1984, Galbert from France firstly used bone cement to treat vertebral hemangioma with success, and then it showed good advantages in repairing bone defects, fracture treatment, treatment of bone diseases, especially in the treatment of metastatic bone tumors, myeloma and other malignant lesions. C. Treatment mechanism: metastatic bone tumor can cause pain, dysfunction and pathological fracture. In bone cement filling treatment, 1, the high temperature generated when the bone cement is polymerized plays a kind of permanent ablation effect on the destruction of tumor cells and nociceptive nerve ending cells. 2, injecting bone cement can improve the biomechanical properties of bone, fix the fibrous bone fracture, reduce the small displacement of bone fracture, eliminate the extrusion and friction between tissues, and reduce the stimulation of nerve endings. 3, bone cement blocks the blood supply to the tumor cells and nociceptors. 4, bone cement is a good treatment mechanism for metastatic bone tumors. of blood supply to tumor cells and pain endings. Therefore, bone cement filling has good pain relief effect on metastatic bone tumor. Advantages compared with conventional radiotherapy, surgical treatment and internal fixation: small trauma, fast onset of action, wide range of indications, fewer complications, accurate positioning under CT guidance, killing most of the tumor cells, and easy to be accepted by late-stage patients. V. Instruments and medicines: The instruments are a complete set of Murphy quick pvp instruments from COOK, including: 11G or 13G, 15.0cm long cephalic end triangular prismatic bone piercing needles and 10ml syringes or domestic stainless steel pressure syringes; the bone cement is a bone cement set provided by Tianjin Synthesis Materials, including polymethylmethacrylate (PMMA) powder and liquid monomer. Sixth, preoperative preparation: all patients should be routine preoperative X-ray film, blood routine, blood coagulation three tests. A 2-mm-thick CT thin-layer examination of the lesion site was performed to understand the degree and extent of osteolytic lesions of the vertebral body, the involvement of the pedicle root, the integrity of the bone cortex, and the involvement of the intervertebral foramen and the spinal canal, as well as to skillfully grasp the position of the needle entry point. Surgical operation: patients were placed in prone position, according to preoperative CT, markers were placed on the surface of the pre-penetration site, the vertebral body was scanned with 2-3mm layers, the puncture route was designed, and the distance and angle of the needle were measured and marked. 2, pillows were placed on the thorax and hips to reduce compression, the head was elevated, and elbow joints and knee joints were lowered. 3, routine disinfection of toweling was done, and the puncture point was soft-tissue anesthetized with 1% lidocaine towards the vertebral bone root. 4, the bone cortex was anesthetized throughout, and the puncture point was placed on a soft-tissue table. Anesthetize the bone cortex, stab the puncture needle to the vertebral root according to the pre-designed angle, the whole puncture process under the guidance of CT step-by-step into the needle, the complete destruction of the healthy side of the vertebral root as a reference, so that the tip of the puncture needle to the anterior part of the lesion, and timely adjustment of the direction of the tip of the needle.4, the PMMA powder, liquid monomer according to the ratio of 20g: 10ml preparation. Just configured bone cement is thin state, this time with a disposable pressure syringe, extract 4-10ml, loaded into the stainless steel tube rotary pressure syringe. When the bone cement was in the form of toothpaste, 1-2 ml was injected into the root of the vertebrae, and the needle was withdrawn while injecting from the front to the back during the injection process. After the injection was completed, the bone puncture needle was retreated to the bone cortex, inserted into the core of the needle, rotated the needle and then withdrawn, and aseptically wrapped up after the local compression and hemostasis. Then CT scan was performed to observe the distribution of bone cement and whether there was any spillage and leakage. Postoperative bed rest for 4-6 hours apply antibiotics for 3-5 days. Complications: There are two main complications: 1, inflammatory reaction caused by heat production of bone cement polymerization, resulting in fever and pain can be relieved by giving anti-inflammatory treatment and symptomatic treatment for 3-5 days after surgery. 2, bone cement leakage into the periphery of the vertebral body, due to its spinal cord, nerve root compression, clinical manifestations of radicular pain and spinal cord compression. Neuralgia can be injected with local infiltration of anhydrous alcohol, persistent radicular pain, surgical removal of the leaking cement is needed. Bone cement filling is a minimally invasive treatment with accurate CT localization, which occurs relatively rarely.