Bile reflux, esophageal multiple ulcers treatment methods are drug treatment and surgical treatment. 1. Pharmacological treatment: commonly used drugs include gastric stimulating drugs, gastric mucous membrane protective agents, proton pump inhibitors, neutralizing gastric acid drugs and so on. (1) Gastric stimulating drugs: such as domperidone, mosapride, etc., are used to promote gastrointestinal peristalsis, reduce gastric acid retention, and avoid gastric acid reflux to stimulate the esophageal mucosa. (2) Gastric mucosal protectants: such as aluminum thiosulfate, bismuth potassium citrate, etc., used to resist bile’s attack on the esophagus and stomach wall. (3) Proton pump inhibitors: e.g., omeprazole, etc., used to relieve symptoms and promote healing of esophageal ulcers. (4) Drugs to neutralize stomach acid: such as aluminum hydroxide, etc., used to neutralize stomach acid and stop the damage of pepsin and bile acid to the esophagus. 2. Surgical treatment: Surgical methods include gastrojejunal Roux-en-Y, endoscopic hemostasis treatment, endoscopic balloon dilatation, etc. (1) Gastrojejunostomy Roux-en-Y: to avoid bile flow through the gastric anastomosis, to prevent bile and pancreatic juice from refluxing into the stomach and attacking the gastric mucosa. It is suitable for patients with severe reflux and patients with combined gastroduodenal ulcer requiring surgical treatment. (2) Endoscopic hemostatic therapy: the purpose is to control bleeding, applicable to patients with bleeding esophageal ulcers. (3) Endoscopic balloon dilatation: a dilator is placed to dilate the narrowed gastrointestinal lumen, applicable to patients with narrowed esophageal lumen. If bile reflux and multiple esophageal ulcers are diagnosed, it is recommended to consult the doctor in time and actively cooperate with the treatment to reduce the adverse effects of the disease.