Low blood pressure in middle-aged people may be primary hypotension, or secondary hypotension caused by thyroid disease, adrenal insufficiency and other diseases, or long-term use of antihypertensive drugs. 1. Primary low blood pressure: Physiological low blood pressure can be caused by thin body size and genetic factors. 2. Secondary hypotension: thyroid disease, adrenal insufficiency, congenital heart disease, chronic heart failure, etc. can cause low blood pressure. Lack of vitamin B12 and folic acid in diet can lead to anemia, which can also cause low blood pressure. Hypertensive patients who have been taking antihypertensive drugs for a long time are prone to postural hypotension, and pregnant women may have low blood pressure during pregnancy. There are many reasons for low blood pressure in middle-aged people, and it is recommended to go to the hospital in time to find out the reasons under the guidance of the doctor and get timely treatment.