Severe hypertension is defined as hypertension grade 3 (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg), and the preferred medication for this group of patients is determined by the patient’s condition. Hypertension grade 3 is usually administered as a combination of drugs, and commonly used antihypertensive drugs include nifedipine controlled-release tablets, irbesartan, and hydrochlorothiazide.
1. Nifedipine controlled-release tablets: belonging to the calcium ion antagonist, the drug can reduce calcium ions through the slow calcium channel into the cell, by reducing the arterial smooth muscle tension to reduce peripheral resistance and blood pressure. Nifedipine controlled-release tablets have a stronger effect, the disadvantage is that it is easy to cause headache and edema.
2. Irbesartan: It is an angiotensin II receptor inhibitor, which can inhibit vasoconstriction and aldosterone release, and produce antihypertensive effect. This drug has a long-lasting effect, the disadvantage is that it is easy to cause headache and palpitation.
3. Hydrochlorothiazide: belongs to diuretics, through the effect of diuretic sodium discharge to achieve the effect of lowering blood pressure, the disadvantage is easy to cause electrolyte disorders.
Patients with grade 3 hypertension need to be treated with more than two drugs at the same time. The combined use of the above three antihypertensive drugs with different mechanisms can make the blood pressure reach the standard as soon as possible.
Severe hypertension requires prompt medical attention to avoid delayed treatment.