Total serum protein is the sum of all circulating proteins. Total serum protein has many functions in the body such as maintaining plasma colloid osmotic pressure, transporting metabolites, participating in coagulation and fibrinolysis, etc. It is not only used for the monitoring of the nutritional status of the body, but also used for the diagnosis and differentiation of diseases. Adult serum total protein concentration (conventional method of bioconjugate): 65-85g/L. Common conditions and causes 1. Elevation: The reason for the elevation of serum total protein is mainly due to the increase of its synthesis or the loss of part of the body fluids. Increased synthesis can be seen in multiple myeloma, macroglobulinemia, etc., and loss of body fluids can be seen in patients with diarrhea, vomiting, high fever, shock, etc.; 2. Decrease: The reasons for the decrease of total serum protein include insufficient synthesis, loss of protein, or increased consumption. Insufficient synthesis is mainly due to liver disease, the ability to synthesize protein decreases. Protein loss is common in nephrotic syndrome, ulcerative colitis, hemorrhage and so on. In the case of increased consumption, the patient may be in a state of pregnancy, the patient has just undergone surgery and is recovering, or there is the presence of hyperthyroidism, tuberculosis, malignant tumors and so on.