There is no such thing as the fastest way to reduce swelling and pain in gout, which generally requires the use of non-steroidal anti-inflammatory drugs such as indomethacin and diclofenac, colchicine and glucocorticosteroids such as prednisone. Due to individual differences, each person has a different sensitivity to drugs and the treatment effect is different. Gout is a metabolic disease caused by purine metabolism disorder. Clinically, there is no such thing as the fastest way to reduce swelling and pain in gout, and in general, the acute stage requires the application of non-steroidal anti-inflammatory drugs as prescribed by the doctor, such as indomethacin, diclofenac, etoricoxib and so on. The use of colchicine in small doses can also be effective in controlling the condition. For patients whose NSAIDs and colchicine are ineffective, glucocorticosteroids such as prednisone and methylprednisolone should be used as prescribed by the doctor. At the same time, ice packs and splints can also be used to reduce pain and swelling in the affected area. Gout is a lifelong disease, it is recommended that patients use medication under the guidance of a doctor, not self-medication, so as not to delay the condition, affecting the therapeutic effect.