Itchy and ulcerated toe crevices are considered to have a high probability of fungal infection, mostly Candida, Trichophyton rubrum or Microsporum canis. A fungal infection of the toe crevices is called tinea pedis, also known as foot fungus. There are many different types of fungi, so if you have itchy and ulcerated toes, you can start with a fungal smear to determine if it is a fungal infection. After a clear diagnosis, you can further do a fungal culture test to determine which type of fungal infection it is, and use the appropriate medication for the different fungi. After confirming the diagnosis of tinea pedis, topical antibacterial drugs such as terbinafine cream, miconazole cream, etc.; when itching is severe, oral antihistamines can be taken; if the infection is serious, oral antifungal drugs such as terbinafine, itraconazole, etc. can be combined. It is recommended to go to the hospital for a clear diagnosis and then drug treatment. In addition, itchy ulcers on the toe seam may also be bacterial infections, common such as Staphylococcus aureus, etc. It is recommended to use topical antibiotics such as mupirocin ointment for treatment, and if accompanied by deep tissue infection, it is recommended to take oral sensitive antibiotic treatment. Patients with itchy and ulcerated toes also need to pay attention to keeping the area dry and breathable, washing every day, changing shoes and socks regularly, and avoiding wearing other people’s shoes and socks. It is recommended that the patient go to a regular hospital in a timely manner, after a clear diagnosis and standardized treatment.