Acute gastroenteritis, if caused by bacterial infection, oral cefixime can play a role, allergy to cephalosporins is generally not recommended. Acute gastroenteritis is associated with acute inflammation of the mucosa of the gastrointestinal tract caused by various physicochemical and biological factors, most commonly seen in viral and bacterial infections, which may cause abdominal pain and diarrhea, nausea and vomiting, fever and chills, headache and other manifestations. If the symptoms are mild, they can be recovered on their own through daily regimen. If the symptoms are obvious, it is recommended to go to the hospital for routine blood and stool tests to determine if it is caused by bacterial infection, and cefixime can be given to fight the infection. It is not recommended for those who are allergic to cephalosporins to avoid symptoms of allergy. Patients with acute gastroenteritis are advised to go to the hospital in a timely manner and take relevant treatment measures in conjunction with the doctor’s advice to avoid further aggravation of symptoms.