Prolactin 1300ng/ml may be caused by pituitary tumor or other causes. Hypothalamic lesions such as craniopharyngioma, ectopic pineal tumors with metastatic tumors can also increase the secretion of prolactin. Pituitary tumors in the prolactinoma will lead to increased levels of prolactin, but the diagnosis of pituitary prolactinoma also needs to be combined with imaging tests, clinical symptoms and other comprehensive judgment. Typical symptoms of pituitary prolactinoma in women of childbearing age are amenorrhea, breast milk overflow, and infertility, and in men, decreased libido, impotence and infertility. In addition, CT and MRI can be used to assist in the diagnosis of pituitary prolactinoma. Once the prolactin level is found to be increased, one should consult the endocrinology department in a timely manner to clarify the cause of the disease and follow the doctor’s instructions to standardize the treatment.