A course of quadruple medication for one stomach still upset may require additional medication. Quadruple drugs usually include proton pump inhibitors, bismuth, two antibiotics. It may be due to the fact that the drugs cause some damage to the gastric mucosa, causing dysbiosis and aggravating the condition, quadruple drugs are suitable for diseases caused by Helicobacter pylori. If the stomach is still uncomfortable after one course of quadruple medicine, you can take the medicine to treat it as prescribed by the doctor appropriately, and if you still don’t get relief after taking the medicine, you need to stop the medicine immediately. Therefore, after taking quadruple drugs a course of upset stomach may still need to take medication. The specific medication method of quadruple drugs needs to be based on the concentration of H. pylori bacteria in the patient’s body, physical condition and a series of other circumstances to make a comprehensive judgment, and then with the drug. Quadruple drugs need to be used under the guidance of a doctor, pregnant and lactating women are prohibited, if infected with Helicobacter pylori, you should immediately go to the hospital to avoid delaying the condition.