Due to blind propaganda, or the pressure of economic indicators in hospitals, a considerable number of doctors ignore the role of conservative treatment of constipation, and even driven by economic interests, they forget the rational choice of drugs for constipation and the principles of scientific taking of drugs. Therefore, this article introduces you to the common drugs for constipation and their indications. I. Western drugs clinically laxative effect of Western drugs including volumetric, osmotic, stimulating, lubricating, motivating drugs and so on. 1, volumetric laxatives also known as bulking agents, mainly for a variety of preparations containing cellulose and psyllium, wheat bran, corn bran, magic yu, agar, methyl cellulose, psyllium preparations, etc.. After absorbing water, it increases the volume and mildly stimulates intestinal peristalsis; after reaching the colon, it is fermented by the bacteria in the intestine, increasing the intestinal osmotic pressure and preventing the absorption of water in the intestine, enhancing the effect of diarrhea. It can be used for a long time, especially in low-fiber diet, pregnancy and retreat of stimulating laxatives. Take care to drink more water when taking it; it should be used with caution in people with intestinal stricture. Oxytetracycline preparation is natural cellulose, can be degraded by bacteria, can cause increased gas production and abdominal distension, part of the occurrence of allergies and asthma and other adverse reactions. Methyl cellulose is a semi-synthetic cellulose, which is partially resistant to degradation by intestinal bacteria. Volumetric laxatives are not effective for all patients with constipation, but can show their efficacy in those cases where the intestine receives insufficient stimulation or lack of stimulation. 2, osmotic laxatives mainly salt and sugar osmotic laxatives. After salt osmotic laxatives are taken orally, a hypertonic environment is formed in the intestine, which can absorb a large amount of water and prevent the intestine from absorbing water to increase the volume in the intestine, such as drinking a lot of water at the same time when taking orally, which can rapidly increase the volume, strengthen the stimulation of intestinal mucosa, enhance intestinal peristalsis, and promote defecation. Clinically, it is mostly used to prepare the bowel before intestinal examination. Excessive or repeated administration of salt laxatives can cause hypomagnesemia, hypernatremia, and hyperphosphatemia. Long-term use should be avoided in cases of fecal impaction, intestinal obstruction, congenital megacolon, and electrolyte disorders. Sugar osmotic laxatives, such as: (1) lactose, can be fermented into monosaccharides by bacteria in the intestinal lumen, increasing the osmotic pressure; (2) sorbitol itself is hypertonic, can carry a lot of water, causing diarrhea, but also often has increased gas production and bloating and other adverse reactions; (3) polyethylene glycol (PEG) polymerization from ethylene oxide, not by enzymatic or bacterial decomposition, its relative molecular mass increased to more than 3000 intestinal (3) Polyethylene glycol (PEG) is formed by the polymerization of ethylene oxide, which is not decomposed by enzymes or bacteria. Compared with lactulose, sorbitol, etc., it is less likely to cause abdominal distension and abdominal pain. 3, stimulating laxatives including anthraquinone-containing laxatives (rhubarb, Frangipani, senna, aloe vera, etc.), fruit guide, castor oil and Bisacodyl, etc. These drugs themselves or their metabolites stimulate the colonic mucosa, intermuscular plexus, smooth muscle, enhance intestinal peristalsis and mucus secretion, promote defecation. Continuous application of these stimulant laxatives can cause watery diarrhea and abdominal pain, and electrolyte disorders such as hyponatremia and hypokalemia. Abuse of stimulant drugs can easily lead to dependence and drug resistance, and cause “laxative colonization”. It is not recommended as a common drug for the treatment of chronic constipation. However, it can be used intermittently when necessary to help remove fecal accumulation in the distal colon. Clinically, it is often used in the preparation of bowel clearance before intestinal examination. 4, lubricating laxatives such as liquid paraffin, glycerin and sodium docusate. Liquid paraffin has the effect of softening stool and is suitable for patients who avoid straining to defecate, such as the elderly and frail, with hypertension, heart failure, aneurysm, and hemorrhoids, hernia, anal fistula and other constipated patients, but it is prone to lipid aspiration pneumonia and perianal leakage. Long-term use can lead to fat-soluble vitamin deficiency and affect carotene, calcium and phosphorus absorption. The laxative efficacy of glycerine preparations such as opiates is based on their stimulating and stool-softening effects and is particularly effective in outlet obstructive constipation with an increased sensory threshold. Docusate sodium (sodium octobutyrate sulfonate) is an anionic surfactant, the drug itself is not absorbed, and when combined with other drugs, it can increase the absorption of the latter in the gastrointestinal tract, thus enhancing the efficacy of the drug, but also enhancing the adverse effects, it is appropriate to short-term (1~2 weeks) for defecation weakness, such as anorectal disorders or post-operative patients in this area. 5, pro-intestinal dynamics drugs mainly effective for slow transmission type constipation, including parasympathomimetic drugs (tranylcypromine, neostigmine), preparations related to 5-HT4 receptors, gastrin agonist erythromycin, CCK receptor blocker cloglutamine, and power/pro-secretory agents have misoprostol, colchicine, etc.; and neurotrophic factor-3. these drugs from different links to promote intestinal dynamics, used to treat Constipation. (1) Tranylcholine is effective in constipation caused by tricyclic antidepressants. (2) Neostigmine, a cholinesterase inhibitor, is effective in reducing intestinal pressure in acute pseudo-intestinal obstruction and has not been evaluated for use in chronic constipation. (3) Among the drugs related to 5-HT4 receptors, cisapride is effective in the treatment of some slow-transit constipation, but it has potential cardiovascular adverse effects in a few patients and has been used sparingly. (4) The receptor agonist tegaserod is effective in the treatment of constipated irritable bowel syndrome (C-IBS) and chronic constipation, increasing the number of stools in patients with (C-IBS), accelerating colonic transmission, and reducing symptoms such as bloating and abdominal pain, suggesting that the drug has both prokinetic and regulatory perception effects. (5) Colchicine is used for the treatment of gout and also for constipation. Colchicine 0.6mg, Tid, significantly increased the number of bowel movements, reduced abdominal distension, accelerated colonic transmission, and increased abdominal pain at the beginning of treatment, while abdominal pain was significantly reduced by the 4th week. For long-term use, attention should be paid to neurotoxicity and hepatic adverse reactions. (6) Prostaglandins such as misoprostol can accelerate colonic transmission and increase the number of bowel movements, and have shown their therapeutic effects in a few cases of severe chronic constipation. (7) Neurotrophic factor (NT-3) promotes the maturation of sensory neurons and regulates neuromuscular synaptic transmission. Recently, a 4-week double-blind placebo-controlled trial showed that NT-3 injections of 0.9 mg three times a week significantly increased the number of bowel movements, improved stool characteristics and reduced straining symptoms, and accelerated colonic transmission. However, since constipation is mainly based on deficiency, “supporting the righteous” plays a leading role in the treatment, and the comprehensive literature combined with our experience suggests that “supporting the righteous” is mainly based on the spleen The main focus is on the spleen, kidney and, to a lesser extent, the qi and blood. The prescriptions of Han Xia Di Xuan Xin Tang, Bai Zi Li Zhong Tang and Bazhen Tang can be added and subtracted to promote the clearing and lowering of turbidity, benefit the qi and nourish the blood, support the yang and help the transportation, and improve the effect of defecation. The conservative treatment measures we use include: ear point pressure bean, Chinese medicine compressing umbilical cord, acupuncture point embedding, Chinese medicine oral administration, Chinese medicine enema, cleansing bowel, Chinese medicine sitz bath, Chinese medicine foot bath, western medicine oral administration, dietary fiber oral administration, biofeedback and so on. According to statistics, 80% of constipation patients have regained the awareness of voluntary bowel reflex through conservative treatment. Regardless of traditional Chinese medicine, western medicine, traditional or modern, it is necessary to consider the patient’s age, physique, concomitant diseases, etc., and choose the treatment method on the basis of evidence or disease identification.