I. Consultation: Mild mastalgia can occur in many women during the premenstrual period. Mastalgia is a worsening of this condition, with an increase in both the degree and intervals of pain, and which needs to be examined and treated? If the pain persists for more than 5 days per month during menstruation and for more than 3 consecutive months, then examination and treatment are required. Classification: Mastalgia is a mixture of various types of pain and can be categorized into cyclic, non-cyclic and extra-mammary pain. Wuhu Maternal and Child Health Hospital, Department of Mammography Xu Rong cyclic pain (54% ~ 70%) non-cyclic pain (22% ~ 30%) pain outside the breast pain breast pathology pain with menstrual cycle changes with ovarian function but no menstrual cycle of cyclic pain (after oophorectomy, hormone replacement therapy) obvious non-cyclic with tenderness postmenopausal mastodynia costochondritis (5% ~ 7%) Gastroesophageal Reflux Disease or Peptic ulcer Cholelithiasis or cholecystitis Cervical radicular pain (4%) Chest wall injury or rib fracture Sore throat Psychological causes or depression (2%) Abscesses Thrombophlebitis of superficial mammary veins Cysts, cystic hyperplasia Dilatation of ducts/periductal inflammation Scarring at biopsy Pain in the breast Adenofibroblastoma. Etiology: It may be multifactorial to cause the disease, and the etiology includes microscopic endocrine changes, malfunction of endocrine response to stimuli, abnormal sensitivity of end organs to minute endocrine changes and changes in local hormone receptors, and psychological factors. 1.Endocrine causes: theoretically, they include increased estrogen, abnormal progesterone levels, luteal insufficiency and abnormal prolactin. 2, Low plasma levels of essential fatty acids and abnormal fatty acids. 3.Psychological basis such as anxiety, psychosis and depression. Examination and evaluation: 1. Taking a detailed and complete history including description of pain, aggravating and relieving factors, patients are evaluated to determine if they need treatment. 2, Have a thorough clinical breast examination. 3, Those with breast pain and abnormalities on palpation need to use appropriate breast imaging, based on age, to determine whether to perform a mammogram or/and ultrasound. 4, In some cases, re-evaluation 8 to 12 weeks after initial diagnosis is beneficial. IV. Handling. 1, many patients with breast pain fear that the pain is related to breast cancer and seek medical treatment, most patients only need follow-up, but for those with persistent severe pain that affects daily life it is appropriate to consider taking treatment measures. 2.Change life behavior: reduce the intake of methylxanthine organisms (caffeine, theophylline, theobromine) . 3.Low fat diet. 4, Wear appropriate supportive bras. 5, drug therapy: such as exogenous hormones, danazol, bromocriptine, evening primrose oil, tamoxifen, luteinizing hormone-releasing hormone analogs, progesterone, local application of non-steroidal anti-inflammatory drugs, etc. . 6. Human kinesiology: massage points. Surgical treatment: surgical removal of breast tissue, ovariectomy, etc. .