It is impossible to determine whether intrahepatic bile duct stones are a major or minor disease. They are essentially benign, but the onset of the disease is often already accompanied by serious complications that are more difficult to cure and have a poor long-term prognosis. Intrahepatic bile duct stones are stones located above the Y-shaped bifurcation of the right and left hepatic ducts, which are not easy to remove, and often lead to bile duct dilatation due to bile sludge caused by bile duct obstruction. Some patients have no obvious symptoms throughout their lives, while some may show symptoms of biliary tract infection such as epigastric pain, epigastric vague discomfort, chills, high fever, and in severe cases, generalized septicemia. Repeated irritation of the bile ducts by stones may be accompanied by nausea, vomiting and other symptoms. Intrahepatic bile duct stones are benign in nature, and early treatment is more effective. However, most of the intrahepatic bile duct stones have serious complications at the onset, such as acute purulent obstructive cholangitis, biliary liver abscess, etc., and the long-term prognosis is poor, and intrahepatic bile duct stones are the high-risk factors for bile duct cancer, which can develop into bile duct cancer, and the prognosis will be relatively poorer. Patients with intrahepatic bile duct stones should pay attention to regular diet in daily life, standardize the treatment under the guidance of doctors, and undergo regular checkups.