Nail exfoliation is a nail disease in which the local nail plate is separated from the nail bed. Antifungal drugs, antiseptic drugs, and glucocorticoid drugs can be applied as prescribed by the doctor to address the cause of the disease. Nail peeling disease may be caused by trauma, long-term contact with irritants, dermatophyte infection and psoriasis, onychomycosis and other diseases, the patient should avoid contact with the triggers, in order to prevent the aggravation of the condition. If the nail peeling disease is caused by dermatophyte infection of the nail bed, it is necessary to follow the doctor’s instructions to use topical ketoconazole, terbinafine and other antifungal drugs to help kill the causative organisms and promote the recovery of the disease. If necessary, sterilizing drugs such as povidone-iodine and glacial acetic acid can be applied to help destroy the germs. If the nail peeling disorder is caused by psoriasis, lichen planus and other factors, it is recommended to follow the doctor’s instructions to use topical glucocorticoid drugs, such as hydrocortisone, dexamethasone, etc., which has the effect of anti-inflammatory and immunosuppressive, and helps to repair the diseased nail. There are many causes of nail peeling disease, we suggest that patients go to the regular hospital to identify the cause of the disease, with the doctor for standardized treatment.