Chronic liver failure in the decompensated stage represents end-stage liver disease, which is mostly caused by various factors such as viruses, schistosomiasis, and alcoholic liver, and the patient’s life expectancy is significantly affected and the end-stage liver disease is irreversible. Treatment is tricky and until a final solution, i.e. liver transplantation, is assured, patients may opt for symptom-specific as well as palliative modalities, including hepatoprotection, vitamin K supplementation, correction of colloid osmotic pressure, maintenance of hydropower balance as well as diuresis, removal of the cause of the disease, and antiviral treatment. The patient’s condition may still be progressing and complications need to be prevented, including gastrointestinal bleeding, hypersplenism, and digestive dysfunction, requiring comprehensive treatment from all disciplines, including integrated surgery, internal medicine, and gastroenterology.