The reason for the large difference between systolic (high pressure) and diastolic (low pressure) pressure in the elderly is likely to be the increased pressure difference caused by atherosclerosis, aortic regurgitation, anemia, hyperthyroidism, etc., and appropriate examinations need to be done. Due to atherosclerosis of the aorta, carotid artery, cerebral artery and other blood vessels, blood vessel elasticity decreases, which affects the location of the peripheral vascular pressure reflection point and the intensity of the pulse wave, so that the pulse wave back to the systolic phase of the large arteries is delayed, and the systolic blood pressure will appear to be increased and diastolic blood pressure decreased, which is manifested as the increase in the differential pressure of the pulse. Dyslipidemia, hypertension, diabetes mellitus, genetics and other factors can damage the vascular endothelium and promote the occurrence of atherosclerosis. In addition, reduced physical activity, dietary imbalance, and elevated blood uric acid are also high-risk factors for the development of atherosclerosis in the elderly. In addition, diseases such as aortic regurgitation, anemia, and hyperthyroidism may also lead to an increase in the differential pressure and require active treatment of the underlying disease. It is recommended that elderly people with underlying diseases should actively cooperate with doctors for treatment, and also pay attention to balanced nutrition in daily life, and appropriately increase the activity level within the tolerable range, so as to slow down the aging of blood vessels.