The treatment of anal fistula is mainly based on surgery, and its drug treatment is mainly symptomatic treatment, including local topical drugs, painkillers and so on. The intermittent period of anal fistula usually has no obvious clinical manifestations, during this period usually do not need to carry out drug treatment. In the acute attack period, the treatment is mainly based on surgery, if the local pus infection is serious and other reasons lead to surgery can not be carried out immediately, you can use drugs for symptomatic treatment. If the acute phase of the disease appears local pus, severe pain, swelling and other symptoms of infection is serious and can not be operated, can be used externally potassium permanganate sitz bath, local application of erythromycin ointment, etc. for treatment, in addition to oral penicillin and other anti-infective drugs treatment. For those with severe pain after surgery, drugs such as celecoxib can be used for intervention. The above drugs need to be used under the guidance of clinicians; the emergence of anal fistula timely consultation.