The full name of intestinal chemosis is intestinal epithelialization, and there are no definitive medications to reverse this pathological change. Intestinal epithelialization is a pathological change in which the gastric mucosal epithelium is replaced by intestinal mucosal epithelium. Intestinal epithelialization belongs to the pathological changes of atrophic gastritis, which is a precancerous lesion. At present, there is no clear drug that can reverse this pathologic change, and the main focus is on symptom control and regular review. Symptom control can choose omeprazole, domperidone, compound digestive enzymes and other drug treatment, such as Helicobacter pylori infection should be actively eradicated. If polyps or early gastric cancer is found, it should be actively treated with surgery. For the question of how long can intestinal chemosis be cured, it is recommended that regular consultation and review be conducted to avoid its further development and the formation of malignant tumors. The medication should be taken in accordance with the doctor’s prescription.