Liver disease usually requires liver function, alpha-fetoprotein, abdominal ultrasound and other tests. 1. Liver function tests: they can determine the degree of liver damage and help identify the cause of the disease. (1) Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamyl transpeptidase, etc., which can reflect the degree of damage to the liver cells as well as indicate the presence or absence of bile duct obstruction. (2) Direct bilirubin, total bilirubin and total bile acids can determine the degree of jaundice and identify hepatocellular jaundice, biliary tract obstruction jaundice and hemolytic jaundice. (3) Albumin and prothrombin time can reflect the synthesis and reserve capacity of the liver. 2. Alpha-fetoprotein: Alpha-fetoprotein is a specific indicator for diagnosing primary liver cancer. Persistent elevation of alpha-fetoprotein suggests the possibility of primary liver cancer. 3. Abdominal ultrasound: It mainly observes the smooth surface, envelope, volume, morphology, parenchymal echogenicity and distribution of the liver, whether there are hypoechoic nodules, and whether there are abnormalities in the size of the spleen and portal vein system. If there is any abnormality, CT or MRI of the upper abdomen can be further improved. In addition, virus screening and autoimmune indicators can be done to clarify the cause of liver disease. When patients present with liver disease, it is recommended to seek medical treatment in time, follow the doctor’s instructions for further examination, and choose a reasonable treatment plan under the doctor’s comprehensive analysis.