The yellowing of the palms of the hands that occurs in patients with hepatitis B is most likely not caused by hepatitis B. If the yellowing of the palms of the hands is caused by hepatitis B, it may be jaundice. In addition to yellowing of the palms of the hands, jaundice may also be evident as yellowing of the skin, as well as yellowing of the urine, or yellowing of the sclera of the eyes. If other locations are not yellow and only the palms of the hands are yellow, this means that it is not caused by jaundice. Patients with hepatitis B who have abnormal palms may have hepatic palms, which usually appear when cirrhosis is more evident and do not appear in the center of the palm, but have faint red blood or reddening between the greater and lesser fissures. The palms of the hands of hepatitis B patients usually do not appear yellow alone, as many normal people can also have yellow palms, which simply means that the blood supply in this location is not particularly rich.