Perianal eczema can be treated with creams such as antipruritics, glucocorticosteroids, and calcium-modulated phosphatase inhibitors. 1 Anti-itching agent. Subacute eczema can be smeared with oils, creams and pastes, such as zinc oxide paste and glycerite lotion. 2.Glucocorticoid. Chronic limited mild perianal eczema, you can apply hydrocortisone cream, moderate can apply mometasone furoate cream, severe can apply halometasone cream and so on. 3. Calcium-modulated phosphatase inhibitors. Such as pimecrolimus, tacrolimus ointment, etc., generally used in patients who should not use glucocorticoid ointment or have contraindications to glucocorticoid use. 4. Antibiotics. Mainly used for patients with ulcers on the surface of lesions, commonly used fusidic acid, mupirocin ointment and so on. The above drugs should be used under the guidance of a professional physician, not self-medication.