Rheumatoid arthritis pain relievers are mainly non-steroidal anti-inflammatory drugs (NSAIDs), which are often used in combination with disease-improving anti-rheumatic drugs. Clinically, NSAIDs are commonly used to relieve pain symptoms in patients with rheumatoid arthritis, such as Loxoprofen sodium, etoricoxib, etc. However, they cannot control disease progression, and need to be used in conjunction with condition-improving antirheumatic drugs, such as methotrexate and leflunomide, in order to inhibit the progressive tissue and joint damage fundamentally. Common adverse effects of NSAIDs are epigastric fullness and discomfort, abdominal pain, nausea, vomiting, acid reflux, loss of appetite, dizziness and headache. They are contraindicated in patients who are allergic to NSAIDs. Avoid taking more than two NSAIDs at the same time when using to reduce adverse reactions. The precautions for the use of different drugs are different, all drugs should be used in accordance with the doctor’s instructions. Rheumatoid arthritis painkillers are recommended to the rheumatology and immunology department of the regular hospital for detailed consultation, and follow the doctor’s instructions to take medication.