Hypopituitarism (Simon-Sihan syndrome) is a clinical syndrome that presents with inadequate secretion of adenohypophyseal hormones due to multiple etiologies, secondary to hypogonadal, thyroid, and adrenocortical function. In Silhan syndrome, the gonads are hypogonadal and the ovaries are significantly reduced in women. The uterus and mammary glands are atrophied. There is a dramatic decrease in the secretion of various hormones due to adenopituitarism, with insufficient secretion of thyroid hormones, adrenocortical hormones, and sex hormones. How to check for hypopituitarism? 1.Pituitary hormone test GH, FSH, LH, ACTH, PRL are reduced. 2, thyroid hormone test TT3, TT4, T3, T4, TSH is reduced. 3.Adrenal hormone test Cortisol, urinary 17-hydroxy, 17-ketone decreased, fasting blood sugar decreased. 4.Sex hormone test Estrogen, progesterone and testosterone propionate are decreased. 5.Blood routine There is often a decrease in hemoglobin and red blood cells, and a decrease in hematocrit. Immunological test So far, the occurrence of Silhan syndrome has not been confirmed to be related to autoimmunity. Immunological test shows that the patient’s blood is negative for anti-pituitary antibodies and negative for pituitary peroxidase antibodies. 7, adenopituitary reserve function measurement (1) thyrotropin-releasing hormone (TRH) happy test: the principle is that TRH can stimulate the anterior pituitary gland to produce TSH and PRL, TRH l00-200μg dissolved in saline 2ml intravenous push, respectively with the injection before and 15, 30, 60min after the injection of 3ml of blood, to determine the TSH and PRL base value and the value of the change after the drug. Changes. The results: Normal TSH peaked at 20-30 min after injection, with a peak value of 6.5-20.5 min/L. If there was no significant increase after TRH injection, it suggested insufficient pituitary reserve function; PRL basal level <25 μg/L rose to 40 μg/L 30 min after TRH injection; if there was no significant increase or the increase was not significant, it suggested insufficient pituitary function. (2) Luteinizing hormone releasing hormone (LH) happy test: 50-100μg of LHRH was dissolved in 5ml of saline and pushed intravenously. 3ml of blood was drawn before and 15, 30, 60 and 90min after injection, respectively, and FSH and LH were measured by radioimmunoassay. 30min after injection, FSH and LH rose 2-4 times in normal patients, if there was no response, it indicated poor pituitary function. Poor function. 8. The rest of the blood test: lower blood sugar, lower hemoglobin, higher eosinophil count.