Seizure-induced movement disorder

Two patients with suspected paroxysmal kinesigenic dyskinesia (PKD) were recently encountered in a consultation. This is a genetic disorder that needs to be differentiated from epilepsy. The disease is briefly described. It is more common in males than in females, with onset in childhood and adolescence and gradual reduction or disappearance of seizures in adulthood. It is mostly inherited in an autosomal dominant fashion. The symptoms are triggered by sudden movements or changes in the speed or amplitude of existing movements. The clinical manifestations may include dystonia (e.g., falling to the ground) or chorea, mostly involving unilateral limbs or throat muscles. The EEG is basically normal during the seizure and interictal periods. Treatment may include carbamazepine.