Pyramidal movement-induced dyskinesia (PKD), also known as pyramidal movement-induced choreoathetosis (PKC), is a rare, sudden-onset dyskinesia disorder in which episodes of involuntary movement are induced by sudden changes in movement. It affects an average of about 1 in 150,000 people. PKD usually develops in children and adolescents, with a predominance of males, and the episodes gradually decrease with age and are self-limiting. PKD is mostly primary, with a genetic family history accounting for about 60% of cases. The mode of inheritance is mostly autosomal dominant, mostly caused by mutations in the PRRT2 gene, and the causative gene is located in the 16p11.2-q12.1 region, which is a type of ion channel disease. PKD and epilepsy may share a common biological basis and ion channel defects, and one of their pathologic mechanisms is likely to be related to Na+ channel defects. A few secondary PKD can be seen in multiple sclerosis, thalamic infarction, traumatic brain injury, perinatal hypoxic encephalopathy, diabetes mellitus, hypoglycemia, hyperthyroidism and so on. Clinical seizures are triggered by sudden changes in movements, such as sudden changes in position or posture, sudden standing, turning, running, etc. Some seizures may be preceded by sensory abnormalities such as limb discomfort, numbness, coldness, etc. Seizures may involve the head and neck, face, limbs and trunk, manifested by involuntary movements on one side or both sides or alternately on the left and right, dystonia, such as limb, hand and foot abduction, writhing and choreography, and sometimes strange facial expressions. Sometimes the facial expression is strange. The duration of the attacks is short (less than 1 minute). The frequency of seizures is several times a month or even hundreds of times a day. The patient is conscious during the seizure and has no discomfort after the seizure. Neurologic examination is normal. There are no abnormal discharges on EEG. Cranial CT or MRI is normal. Although the disease is not epilepsy, small-dose antiepileptic drug therapy is effective, such as carbamazepine, oxcarbazepine, phenytoin sodium, lamotrigine, etc. can reduce or terminate seizures.