The chronic eczema on the hands is generally difficult to cure, but can be relieved by medication and physical therapy. 1. Medication: (1) antihistamines: eczema is generally due to allergic reactions, according to the patient’s condition can choose appropriate antihistamines, such as chlorpheniramine, phenylephrine, ipratropium and other drugs. (2) Topical glucocorticoid preparations: glucocorticoid preparations mainly serve as anti-inflammatory, anti-allergic, anti-itch, etc., which are commonly used in the treatment of eczema. Generally speaking, according to the degree of the disease, choose the appropriate drug treatment, such as the weak drug budesonide cream, medium-acting glucocorticoid tretinoin and so on. (3) Antibiotics: If the patient’s skin is itchy and the scratching leads to secondary infection of the skin, mupirocin ointment, clindamycin gel, etc. are needed. 2. Physical therapy: Ultraviolet therapy is generally used to relieve symptoms by irradiating the affected area with ultraviolet rays, including narrow-spectrum medium-wave ultraviolet rays, long-wave ultraviolet rays irradiation, etc. It usually has a better therapeutic effect on persistent and chronic eczema. There may be other ways to treat chronic eczema on the hands, and any modalities should be performed under the advice of a physician. If any significant discomfort occurs, you should go to a specialized hospital immediately for effective treatment. The above medications should be used as prescribed by a doctor.