Uric acid is a product of purine metabolism. A blood uric acid of 500umol/L indicates an increase in serum uric acid. If a large amount of high purine food, such as animal offal and seafood, is consumed within 3 days of blood collection, an increase in blood uric acid will occur. Serum uric acid will return to normal after stopping the intake of high purine food. Pathological factors need to be considered, seen in the early damage of kidney function, where blood uric acid is mainly filtered through the glomerulus of the kidney. When diabetic nephropathy is present, the glomerular filtration barrier will be damaged and blood uric acid cannot be filtered through the glomerulus into the renal tubules, and blood uric acid will accumulate and increase in the body. It can also be seen in diseases of the blood system, malignant tumors, etc., which will be accompanied by a large amount of cell destruction, and the production of blood uric acid in the body will increase, when it exceeds the amount excreted by the kidneys, blood uric acid will increase.