Swelling of hands after waking up can be caused by tenosynovitis, synovitis, heart, liver and kidney diseases. 1. Tenosynovitis: frequent finger activities can lead to inflammation of the tendon sheath, finger tendons in the tendon sheath edema and compression, can wake up after the hand swelling, stiffness, restricted movement and other uncomfortable symptoms. 2. Synovitis: Hand joint strain or wear and tear leads to inflammation of synovial membrane in the joints, synovitis of finger joints can cause swelling of the joints, and after waking up, it can be manifested as swelling, stiffness of joints, pain, and restriction of activities. 3. Heart, liver and kidney diseases (1) Heart failure: Decreased cardiac function and ejection volume can cause increased resistance to return, resulting in impeded blood return to the hands, which can lead to swelling of the hands after waking up. (2) Hepatic hypoplasia: Hepatic hypoplasia causes albumin synthesis disorder, and low albumin leads to water infiltration into the tissue interstitial space in the blood vessels, which may lead to swelling of the hands and other tissue edema manifestations. (3) Nephrotic syndrome: large amount of albumin is lost, and the rate of loss exceeds the rate of synthesis by the liver, which can also lead to hypoalbuminemia and cause swelling of the hands. 4. Other factors: improper sleeping position during sleep, hand pressure leads to poor venous return, which can lead to hand swelling; diabetes can lead to poor peripheral circulation, followed by the performance of hand swelling. When waking up with swollen hands, you need to consult a doctor in a timely manner, under the guidance of specialists to actively carry out treatment, which will help to improve the swelling of the hands as soon as possible.